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the cities that the have grave of any of fourteen infallibles are holy cities of Shiite.

the grave of Ali (sa) is in Najaf, Iraq. Mashhadd, Iran for Imam reza (sa), Karbala, Iraq for Imam Hussain (sa), Samerra, Medina.

fourteen infallibles are prophet and his daugher and 12 Imams and according to shia the 12th Imam is alive now and leading and supporting Muslims.

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Q: What city had the most important Shia shrine?
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