Among the many causes of the fall of the Roman Empire was wars with Persians, which cost the empire much of its strength. But I believe there were other causes that were more important, including civil wars and invasions of migrating Germanic peoples.
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Back in 539BC, the Persians conquered Babylon.
Roman.
Roman Empire ruled most of the known land at the time.
The Roman Empire reached its greatest extent under the rule of the emperor Trajan who conquered Dacia (much of present day Romania and part of Moldova) in 106 and took Mesopotamia (Iraq) from the Persians in 116
Reorganized it into the Confederation of the Rhine.