Yes. Without long-standing prejudices against the Jews it would have been virtually impossible to demonize them in way that the Nazis did and to try to exterminate them. From a social and political point of view, one cannot simply pick on any group and exterminate it. It has often been said that antisemitism is as irrational as hating people with red hair, but of course 'redheads' have not been demonized and persecuted.
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The antisemitism during the Holocaust was just an exaggerated form of pre-Holocaust antisemitism.
Yes, and the Japanese were completely bewildered by antisemitism.
it affected them by the nazi starting the holocaust
antisemitism is the longest hatred cause in history that still survives today. Among the most common manifestations of antisemitism throughout history were pogroms. The first such incident to be labeled a pogrom is believed to be anti-Jewish rioting in Odessa in 1821. That was in Russia. But this has been practice during millennial.
This is a difficult question, but I think it did not actually make any change to the status of Jews in America. (Obviously, as public awareness of the Holocaust grew, antisemitism became less acceptable).