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Primarily because they may cause phlebitis or tissue necrosis if given undiluted. This may be because of the acidity/alkalinity of the product, or the high osmolarity of the solution. One common example is an anti-nausea medication called Phenergan, which often causes pain if given undiluted and has even caused loss of fingers due to necrosis and tissue destruction.

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Q: Why some intravenous medications need to dilute before administering?
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