MDMA (methaldyoxidemethamphemtamines) have various negative affects. Probably the most noticeable being depression for a few days after use. It also affects short term memory during and even after the drug is out of one's system. All the brain's serotonin is released into the body and can affect the part of the brain that creates serotonin. It has been known to cause anxiety issues within heavy users as well as memory loss or even brain damage depending on how extreme the use is. Serotonin depletion can be countered by taking a supplement such as 5-HTP after MDMA use. Many scientists believe that most mental damage caused by clubbers taking MDMA is caused more by sleep deprivation than the MDMA itself. Although MDMA has been projected as an extremely harmful drug by the media, scientific studies have shown that it is far less harmful than legal drugs such as tobacco and alcohol. In fact, UK deaths attributed to "ecstasy" represent less than one tenth of one percent of deaths attributed to legal pain killers. For a graph of the harmfulness of drugs see here: http://newsimg.bbc.co.uk/media/images/41949000/gif_41949092_drugs_graph_416.gif
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