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L-Dopa is a prodrug used to treat Parkinson's Disease. It crosses the blood brain barrier with the aid of Phe-Trp-L-aromatic acid transporters and is then turned into dopamine through decarboxylation. However, it is also capable of producing large amounts of dopamine in peripheral areas by stimulating the chemoreceptor trigger zone and these dopamine can produce side effects in peripheral body parts. Carbidopa is hence added to inhibit DOPA decarboxylase in peripheral areas so that there will be fewer of these side effects.
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Earn +20 ptsQ: Why is Carbidopa admistered with L-Dopa?
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