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Neostigmine is a competitive reversible inhibitor of acetylcholinesterase. When the drug interacts with the serine of the enzyme's active site, a nucleophilic substitution reaction takes place where the drug loses a phenol group leading to the formation of a stable intermediate. However, serine then gets capped by a stable urethane group. Hydrolysis then occurs preventing "aging" from happening. The serine will then return to its normal form so this inhibition is reversible.
Neostigmine contains an ester functional group and a quaternary nitrogen with a positive charge. Meanwhile, the active site of the acetylcholinesterase has a serine residue and an anionic site. The ester functional group can hence form a hydrogen bond with the serine residue and the quaternary nitrogen can be electrostatically attracted to the anionic site. In addition, neostigmine may also contain methyl groups which fit into the enzyme's hydrophobic spaces. Neostigmine can hence inhibit acetylcholinesterase in a reversible manner.
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What are Factors that inhibit interoperability?
Interoperability is the ability to make organizations to work together in an efficient manner. Argumentative behavior, inconsistency, and unreliability can inhibit interoperability.
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What is is the homophone for manner of walking?
gait
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Vigorous manner.
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transparent manner.
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manner of acting
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What does mannerism mean in drama terms?
the manner someone speeks in like good manner or bad manner or funny manner etc. source: my knowlege
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He has a friendly manner. Her friendly manner has gained her many friends. He would be more well liked if he had a friendly manner.
