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Because MDMA (Ecstasy) causes a flood of serotonin in your brain. Serotonin is the chemical that creates a sense of well-being and balances your mood. Ecstasy causes all the serotonin in your brain to be released at once.
That is why people often feel depressed and unhappy for a day or so after taking Ecstasy. All of the serotonin in their brain has been depleted, and it takes awhile for your brain to replace it.
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