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HLA is codominantly expressed because this gives the greatest variety and therefore the biggest chance MHC will have to bind to a peptide.

MHC class 1 can bind up to 10 peptides and it is anchored 4x which makes it much more strict in terms of ability to the range it can bind compared to MHC class 2 which can bind up to 50 peptides and only anchors 2x.

e.g. If you only had your mothers HLA-A, your MHC wouldn't be able to identify whatever peptides that specific HLA-A (mom's) had the ability to bind to.

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13y ago
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Q: Why are HLA codominantly expressed?
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