Alcohol does not directly affect the action of most antibiotics. There are exceptions, and you should consult a pharmacist or read the materials that come with the prescription.
That said, drinking alcohol has a depressant effect on bodily functions including, to some degree, the immune system. It can also affect the body's ability to regulate its temperature. Finally, alcohol is a diuretic (causes the body to excrete fluids) and too much can lead to dehydration at a time when the body is in need of even more liquids than usual.
In short, a little booze is OK, but staying drunk until you are over your cold doesn't cut it when it comes fighting off and recovering from an illness.
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