I just went to donate plasma for the first time today and I am taking spironolactone. The doctor told me that spironolactone is a diuretic and thins your blood and so in conjunction with the blood thinners they use in the donation process, it is not safe to donate. So I will not be allowed to donate until 48 hours after I have stopped taking spironolactone.
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probably not as it would be present in the blood system. to be certain check with your GP or with the blood donor organisation group.