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Basophils are the granulocytes that produce and release histamine. Histamine is involved in the inflammatory response and allergic reactions.
Histamine
Mast cells produce histamine in response to allergies. Histamine is a key inflammatory substance that contributes to allergy symptoms such as itching, swelling, and redness. When allergens are detected, mast cells release histamine, leading to an inflammatory response that helps the body fight off perceived threats.
Actualy white blood cells release histamine.
Histamine is released by basophils and mast cells in near by connective tissue which is an immune response to foreign pathogens.
Basophils primarily release histamine and other pro-inflammatory molecules in response to allergens. They do not secrete hormones like the endocrine glands, such as the pituitary gland, which releases hormones like growth hormone or thyroid-stimulating hormone.
They are released by basophils and mast cells in nearby connective tissue.
The rarest type of white blood cells (WBCs) that release histamine and can exaggerate the inflammatory response are basophils. These cells account for less than 1% of the total WBC count and play a crucial role in allergic reactions and inflammatory responses by releasing histamine and other mediators. Their activation contributes significantly to the symptoms of allergies and asthma, enhancing vascular permeability and promoting inflammation.
Histamine release can be stimulated by various triggers such as allergens, physical injury, stress, and certain types of drugs. When the immune system detects these triggers, it releases histamine as part of the inflammatory response.
Histamine is the non-hormonal chemical messenger secreted by mast cells that contributes to the inflammatory response. It causes vasodilation, increased vascular permeability, and smooth muscle contraction, leading to symptoms like redness, swelling, and itching.
Histamine itself does not directly cause eczema, but it can play a role in the condition's symptoms. Eczema, or atopic dermatitis, is primarily associated with an overactive immune response and skin barrier dysfunction. When the skin is inflamed, histamine is released, which can lead to itching and redness. Therefore, while histamine is involved in the inflammatory response, it is not the root cause of eczema.
Mast cells are the connective tissue cells that produce histamine in response to various stimuli, such as allergens or injury. Histamine is a key mediator of inflammation and allergic responses in the body.