The preferred position of comfort for most patients with respiratory distress is the Fowler's position (sitting up). A prone, supine, or lateral recumbent position would make it more difficult for the patient to breathe.
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In the old days of first aid, the prescribed position for difficulty in breathing was to place the patient in a "tripod" position. The "tripod" position stated for the patient to sit leaning forward with their arms resting on their thighs.
Whilst this method is still recommended for shortness of breath (SOB), Asthma and other cases of breathing difficulties, the need for the patient's comfort is now emphasised. In light of this, the patient should be placed in the position that is most comfortable, while taking into account the benefits of the "tripod" position.
It is also worthwhile to note that a patient who is uncomfortable and agitated will only result in their condition worsening so it is up to the first aider to make a compromise between comfort for the patient and the benefits of the tripod position.