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The peripheral nerves of the autonomic system, and then the internal nerves, would respond to increased body temperature. The hypothalamus would trigger the nerves that cause various anatomical responses, such as blood vessels rising toward the surface of the skin, sweat glands increasing perspiration, heart (pulse) rate increase, and the diphragm beginning a faster, shallower breathing rate to cool the lungs.

The nerve responses to unalleviated temperature increase include muscle twitching, spasms, and extreme thirst. Thereafter, overheating overpowers the nerves. Muscle activity and brain activity will begin to shut down, as the body tries to limit its heat output. Perspiration will cease, in order to conserve moisture for the vital organs.

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