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Drugs which are administered percutaneously, sublingually, or have to cross the blood brain barrier have to be lipophilic.
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∙ 6y ago
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Is an ionized drug more lipophilic or less lipophilic?
An unionized drug tends to be lipophilic (and hence, would be hydrophobic). Thus, an ionized drug on the other hand would be lipophobic (i.e. the opposite of lipophilic), lipid-hating.
Why is drug metabolism needed?
Drug metabolism is needed is lipophilic drugs cannot be cleared renally. These lipophilic drugs need to be metabolised into more polar products so that they can be excreted in the urine.
What is lipophilic?
Lipophilic is a substance that dissolves in or mix consistently with lipids.
In what kinds of professions is drug testing acceptable?
In what kinds of professions is drug testing acceptable and in what kinds of professions is it not
What is the nature of solute?
the nature of interaction depends on whether they are lipophilic or hydrophilic. if both are hydorphilic ionic interaction, both lipophilic hydrogen bonding. ionic if lipophilic-hydrophilic.
What is the nature of solute-solvent interaction?
the nature of interaction depends on whether they are lipophilic or hydrophilic. if both are hydorphilic ionic interaction, both lipophilic hydrogen bonding. ionic if lipophilic-hydrophilic.
What happens during the biphasic process of drug metabolism?
Phase I: Lipophilic drugs need to become more polar so that they can be excreted in urine. New polar functional groups hence need to be unmasked for added to them. This can happen via oxidation, reduction, or hydrolysis.Phase II: The original drug or drug metabolites gets conjugated to acetate, sulfate, glutathione, or glucuronic acid. They can hence be excreted even more quickly due to their increased polarity.
Why is Xenon lipophilic?
Yes. Xenon is lipophilic and exhibits affinity for cavities in macromolecular interiors. Xenon's lipophilic behavior has been shown from its partition with long-chain hydrocarbons and from its in vitro and in vivo partition with fatty tissue.
Can you explain hydrophilic lipophilic?
Hydrophilic means something that is attracted to or absorbed by water. Lipophilic is something that is attracted to or absorbed by fat.
Are steroids lipophilic?
Yup. They sure are.
Which pesticides are most lipophilic?
Lipophilic pesticides are those that are soluble in the fatty tissues of animals such as fish and people. DDT is the main pesticide with this quality.
What are the differences between 'lipophilic' and 'hydrophobic'?
they are the same.
