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Is an ionized drug more lipophilic or less lipophilic?
An ionized drug is generally less lipophilic than its non-ionized form. This is because ionization usually results in the drug having a greater affinity for water rather than lipid-based environments.
Why is drug metabolism needed?
Drug metabolism is needed to convert foreign substances like drugs into compounds that can be easily eliminated from the body. This process helps to detoxify and remove potentially harmful chemicals from the body, ensuring they do not accumulate to toxic levels. Additionally, drug metabolism can activate certain medications, making them more potent or effective.
In what kinds of professions is drug testing acceptable?
In what kinds of professions is drug testing acceptable and in what kinds of professions is it not
What is the nature of solute?
the nature of interaction depends on whether they are lipophilic or hydrophilic. if both are hydorphilic ionic interaction, both lipophilic hydrogen bonding. ionic if lipophilic-hydrophilic.
What is the nature of solute-solvent interaction?
the nature of interaction depends on whether they are lipophilic or hydrophilic. if both are hydorphilic ionic interaction, both lipophilic hydrogen bonding. ionic if lipophilic-hydrophilic.
What happens during the biphasic process of drug metabolism?
Phase I: Lipophilic drugs need to become more polar so that they can be excreted in urine. New polar functional groups hence need to be unmasked for added to them. This can happen via oxidation, reduction, or hydrolysis.Phase II: The original drug or drug metabolites gets conjugated to acetate, sulfate, glutathione, or glucuronic acid. They can hence be excreted even more quickly due to their increased polarity.
Why is Xenon lipophilic?
Yes. Xenon is lipophilic and exhibits affinity for cavities in macromolecular interiors. Xenon's lipophilic behavior has been shown from its partition with long-chain hydrocarbons and from its in vitro and in vivo partition with fatty tissue.
Can you explain hydrophilic lipophilic?
Hydrophilic means something that is attracted to or absorbed by water. Lipophilic is something that is attracted to or absorbed by fat.
Are steroids lipophilic?
Yup. They sure are.
What is the definition of lipophilic?
Lipophilic means having an affinity for or the ability to dissolve in fats, oils, and other nonpolar solvents. Lipophilic substances tend to accumulate in fatty tissues and cell membranes.
Does all non polar molecules are lipophilic?
Not all nonpolar molecules are lipophilic, but most lipophilic molecules tend to be nonpolar. Lipophilic molecules are attracted to fats and oils, so they typically do not mix well with water. Nonpolar molecules lack a significant difference in electronegativity and, as a result, do not easily dissolve in water.
What is lipophilic?
Lipophilic refers to substances or molecules that are attracted to and able to dissolve in fats, oils, and lipids. This term is often used in the context of pharmaceuticals to describe substances that have an affinity for fatty tissues in the body.
