The knees are the weakest joints in our body. Although medical science has increased our life expectancy to 75-plus years, our knees can only take 35-40 years of use. After that, the ligaments and tendons that hold the joint together weaken and stretch, and the cartilage between the bones deteriorates.
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In my opinion, I would say that the transversus linguae, or your tongue, would be based amount of work it does. Work being force x distance. Because of the origin and the insertion of this muscle, the "work" that it is able to do is relatively small.
The weakest bone in the human body is...wait for it... your heel because it saves you from falling and does some other stuff but not very important stuff like saving a life.
There are vital body point wherein you should protect from any hit or injury. These bones can be easily damaged if not well protected. For the list, check the link below.
The wrist is the weakest part of the arm. The majority of the arm is very stable and strong, therefore bones do not frequently break in the other areas of the arm.
The weakest part of a females body is actually her ovaries. However because they are protected inside their abdomen they very rarely, if ever, get hurt.