In moderm medical practice, prochlorperazine is most often used for the treatment of vertigo and nausea and vomiting. The drug was formerly used to treat psychosis and the manic phase of bipolar disorder, but is now rarely used for that purpose. In the United Kingdom, prochlorperazine maleate has been made available as as an over-the-counter treatment for migraine headaches.
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Prochlorperazine may be used to control the nausea and vomiting that occur during recovery from the general anesthetics used in surgery.