0
The p53 Tumour suppressor gene is located on chromosome 17. As its name suggests, it has an anti-tumour activity. That involves the overseeing of the cell cycle. If either the cell or the DNA is impaired, p53 activates the production of specific chemicals (like p21 protein), which interferes with the cell cycle. Depending on the nature/extent of the damage, its either repaired, thus cell cycle is allowed to continue, or p53 initiate apoptosis (cell death).
This mechanism would effectively stop the proliferation of infected (malignant) cells, however, p53 itself (or any of genes/chemicals p53 regulates) could be damaged/mutated. In the inherited condition, Li-Fraumeni syndrome, for example, only one functional copy of p53 gene is inherited (instead of two), which interferes with its normal function.
Wiki User
∙ 14y ago
Add your answer:
Earn +20 pts
What role does liver play in the life cycle of red blood cell?
what role the liver play in the life cycle of red blood cells
What role do wetlands play in the water cycle?
it acts as the collection point or storage in the hydrologic cycle
What is the role of proteolytic enzymes in the cell cycle?
It separates the chromosomes during mitosis.
What is the role of a single cell organism in the oxygen cycle?
I see why you're a nerd
Function of cyclin in the cell cycle?
The role is cyclins is to bind with Cdks to propel the cell through the next stage of the cell cycle as they are regulatory subunits. The cyclin part of the complex formed after binding with the cyclin-dependent protein kinase. Cyclin levels are very high especially when the cell is ready to progress to the next stage of the cell cycle, and after the cell is in the next stage, the cyclins are degraded until they are needed by the cell again.
How does cytokinesis play an important role in the cell cycle?
Cytokinesis takes place after meiosis I and II or mitosis where cell division takes place and divides the cell into two daughter cells.
Describe the role of checkpoints in the onset of cancer?
Cell cycle checkpoints are used by the cell to monitor and regulate the progress of the cell cycle. Checkpoints prevent cell cycle progression at specific points, allowing verification of necessary phase processes and repair of DNA damage. The cell cannot proceed to the next phase until checkpoint requirements have been met. Several checkpoints are designed to ensure that damaged or incomplete DNA is not passed on to daughter cells. Two main checkpoints exist: the G1/S checkpoint and the G2/M checkpoint. G1/S transition is a rate-limiting step in the cell cycle and is also known as restriction point. An alternative model of the cell cycle response to DNA damage has also been proposed, known as the postreplication checkpoint. p53 plays an important role in triggering the control mechanisms at both G1/S and G2/M checkpoints. Impaired spindle checkpoint function has been found in many forms of cancer. The BRCA1 tumor suppressor plays a role in the activation of human chk1, therefore the posreplication checkpoint may prevent the genetic changes that lead to cancer. Mutations in factors contributing to cell cycle arrest at the restriction point are thought to be the main contributors of cancer. hope this helps!
What is the role of leaching in the nitrogen cycle?
role of leaching in nitrogen cycle
What is the role of needs in business cycle?
explain the role of needs in the business cycle
What does the ocean role in the water cycle?
Oceans have important role. It is a part of water cycle.
What is mans role in the water cycle?
Man has no role in the water cycle. Neither can the duplicate it.
What cycle does the atmosphere not play a role in?
In nitrogen cycle
