Opioids work by binding certain receptors in the brain Which enhances the effects of certain neurotransmitters in the brain that alter the sensation of pain. Dopamine, and endorphins are two natural chemicals in the brain that are capable of pain relief.
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Opioid analgesics relieve pain by acting directly on the central nervous system. However, this can also lead to unwanted side effects, such as drowsiness, dizziness, breathing problems, and physical or mental dependence.
The mechanism of action of opiates is to target the pain receptors in the brain; the mechanism of action of NSAIDS is to work at the site of action, or the actual area in the body where there is pain; for example, if one experiences pain in the knee, the NSAID works directly at the knee and reduces the pain. For much more severe pain, an opiate 'disguises' the pain by making the receptors in your brain not recognize the pain elsewhere in your body.
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