Negative intrathoracic pressure is the normal pressure in the area between the pleura of the lungs and the chest wall. The pressure is considered negative because it is less than the atmospheric pressure.
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Intrathoracic pressure is the pressure inside of the pleural cavity. It is also called intrapleural pressure and the normal pressure is called negative pressure.
As you inspire, the diaphragm descends, it causes a further decrease in negative intrathoracic pressure, which increases the flow of blood out of vena cava into the right side of the heart.