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In researching this question myself I found the most straight forward answer from: http://www.drugs.com/mmx/acetazolamide.html Here is a quote from that page: Half-life:

Acetazolamide (tablets)-10 to 15 hours. {14}

Methazolamide-14 hours.

Time to peak concentration:

Acetazolamide tablets-2 to 4 hours after a 500-mg dose.

Acetazolamide extended-release capsules-8 to 12 hours after a 500-mg dose.

Peak serum concentration:

Acetazolamide tablets-12 to 27 mcg per mL with a 500-mg dose.

Acetazolamide extended-release capsules-6 mcg per mL with a 500-mg dose.

Elimination:

Acetazolamide-Renal; as unchanged drug; 90 to 100% of a dose is excreted within 24 hours after administration of oral tablets or intravenous injection; 47% of a dose is excreted within 24 hours after administration of extended-release capsules.

Dichlorphenamide-Unknown.

Methazolamide-Renal; 15 to 30% excreted unchanged. Remainder unknown.

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16y ago

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