The only way to get malignant hyperthermia is (1) have the genes and (2) get a drug called succinylcholine, which is used to paralyze muscles for surgery.
yes....................
yup there is treatment
yes
which is a late clinical sign associated with the end stges of malignant hyperthermiia
Malignant hyperthermia is anesthesia induced and causes genetic predisposed individuals to suffer from uncontrolled increase in skeletal muscle oxidative metabolism. This overwhelms the body responses and may lead to circulatory collapse, necrosis , gangrene and death.
Arthur Lazarus has written: 'The neuroleptic malignant syndrome and related conditions' -- subject(s): Adverse effects, Antipsychotic drugs, Catatonia, Major Tranquilizing Agents, Malignant hyperthermia, Neuroleptic malignant syndrome, Side effects
The usual diagnostic criteria for neuroleptic malignant syndrome includes the presence of hyperthermia (temperature over 38?C or 101?F) with no other assignable cause, muscle rigidity.
Malignant hyperthermia is a potentially life-threatening condition triggered by certain medications used during anesthesia. It results in uncontrolled hypermetabolism, leading to high fever, muscle rigidity, and potentially dangerous metabolic imbalances such as increased oxygen consumption, acidosis, and electrolyte abnormalities. This metabolic storm can be fatal if not promptly diagnosed and treated.
Dantrolene is a muscle relaxant that appears to work to prevent the release of calcium. After the widespread introduction of treatment with dantrolene, the mortality of malignant hyperthermia fell from 80% in the 1960s to less than 5%. Azumolene has also been shown to be as effective as dantrolene.
Jiefei Tong has written: 'Defects in the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum that are associated with malignant hyperthermia and central core disease'
Drug of Choice has 166 pages.