Alzheimer
Enzymes
Tay-Sachs disease is a human genetic disorder which results in the accumulation of cells due to the clogging caused by undigested lipids. The organelle involved in this disease is the lysosome.
The lysosome must be involved in Tay-Sachs disease. Lysosomes are responsible for breaking down cellular waste, including lipids. In Tay-Sachs disease, a deficiency in the enzyme beta-hexosaminidase A leads to the accumulation of lipids in cells, particularly in the lysosomes.
In Pompe's disease, the defect lies in the lysosomal enzyme alpha-glucosidase, which leads to the accumulation of glycogen in lysosomes. In Tay-Sachs disease, the defect is in the enzyme hexosaminidase A, which leads to the accumulation of GM2 gangliosides in lysosomes.
A disease may develop when one or more of the body's organs malfunction.
Lysosomes
lysosomes
Lysosomes are the organelles that become defective in these diseases.
Lysosomes are responsible for digesting worn out organelles. If there was not a lysosome, then excess organelles would not be discarded. Tay-Sachs disease is caused by malfunction of lysosomes or one of their digestive proteins.
Addison's disease results from damage to the adrenal glands. This causes under activity of the adrenal cortex with low or no production of the steroid hormones. It is caused by tuberculosis, amyloidosis, severe septicaemia, and damage to the adrenal glands during abdominal surgery. Long term steroid supplements are need to manage this condition.
Lysosomes are cellular organelles responsible for breaking down waste materials and cellular debris. In Alzheimer's disease, the accumulation of misfolded proteins, such as amyloid-beta and tau, can overwhelm lysosomes, leading to their dysfunction. When lysosomes release destructive enzymes, it can result in cellular damage and inflammation, exacerbating neurodegeneration and contributing to the progression of Alzheimer's disease. This disruption in cellular homeostasis plays a critical role in the pathology of the disease.
A disease is when you have a body malfunction or an organ is not working right.