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Nothing honestly, triple antibiotic cream is just a cheap for of neosporin. You can use either of them if you'd like, they both are safe and effective.

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Q: What is the difference between neosporin and triple antibiotic cream?
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Can Triple Antibiotic Ointment be used for treatment of athelete's foot?

No. Athlete's foot is caused by a fungus. Triple Antibiotic (Neosporin) treats only bacteria, not fungus.


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Neosporin is an antibiotic with three components...neomycin sulfate, polymixin B sulfate and bacitracin. If this combination is in ointment form, many times you will find it called "triple antibiotic ointment" or it's Trade name, Neomycin. Polysporin is a combination of two antibiotics, bacitracin zinc and polymixin B sulfate. By combining the three antibiotics, one may treat or prevent a wider range of bacterial infections. For more information see the Related Link. If you are allergic to penicillan, you should use Polysporin, instead of Neosporin to avoid potential hives.


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