Extracellulary, Sodium is major ion. Intracellular concentration of sodium is: 12 mEq/L
Extracellular concentration of sodium is: 140 mEq/L
Intracellularly, Potassium is major ion.
Intracellular concentration of Potassiumis: 140 mEq/L
Extracellular concentration of Potassiumis: 3.5-5 mEq/L
These concetrations are maintained by Na+/K+ ATPase.
The concentration of sodium inside a neuron is lower than outside due to the activity of the sodium-potassium pump. Specifically, the concentration of sodium ions is higher outside the neuron at around 145mM, compared to around 10-15mM inside the neuron.
The inside of a resting neuron is negatively charged compared to the outside, due to the higher concentration of negatively charged ions inside. Specifically, at resting membrane potential, there is a higher concentration of sodium ions outside the neuron compared to inside.
The sodium ion concentration is higher on the outside of the cell and potassium ion concentration is higher on the inside of the cell
The concentration of potassium ions inside the cell is typically higher than it is outside the cell. This concentration gradient is maintained by the sodium-potassium pump, which actively transports potassium ions into the cell. This imbalance in potassium concentration is important for various cellular processes, such as maintaining the cell's resting membrane potential.
The inside of cells have a higher concentration of potassium ions compared to the outside of the cell. This concentration gradient is maintained through the action of ion channels and pumps in the cell membrane.
Outside a neuron, there are mostly sodium ions but some potassium ions. Inside the neuron, there are only potassium ions. Since both sodium and potassium are positive ions, and they are in a higher concentration outside the cell, that makes the outside have a more positive charge than the inside. But for all intents and purposes, the outside is positive, and the inside is negative. When the sodium ions (Na+) rush into the cell during depolarization, it causes the concentration of positive ions inside the cell to go WAY up, making the inside more positive than the outside. This means that the outside is now negative and the inside now positive.
Potassium ions (K+) are found in high concentration inside the neuron compared to outside. This concentration gradient is maintained by the sodium-potassium pump.
the sodium-potassium pump, an active transport protein that uses energy from ATP to move sodium ions out of the cell against their concentration gradient.
The cell could use active transport to move sodium against its concentration gradient from outside the cell to inside the cell. This process requires energy in the form of ATP to pump sodium ions against their concentration gradient.
The lower the amount of ATP, especially if there is none present, the concentration of amino acids outside of the cell will be much greater than on the inside, because amino acids need to be aided by a sodium ion. Sodium is pumped outside of the cell (where the amino acids are) by the sodium-potassium pump which needs ATP to function; therefore, if there is no ATP, the pump will not operate, there will be no sodium ions on the outside to aid amino acids into the cell.
This describes the ionic distribution across the cell membrane, where sodium (Na+) concentration is higher outside the cell and potassium (K+) concentration is higher inside the cell. This gradient is maintained by the sodium-potassium pump, a vital mechanism for cell function including nerve impulse transmission.
The resting potential is the normal equilibrium charge difference (potential gradient) across the neuronal membrane, created by the imbalance in sodium, potassium, and chloride ions inside and outside the neuron.