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Clinical studies demonstrate that 2 tablets (400 mg total) a day is an effective level of supplementation for most people or as directed by your qualified health consultant. The best time to take SAM-e is before meals on an empty stomach. Depending on the condition of the individual, some people may achieve greater benefits with a higher level of supplementation. When taking SAM-e be sure to follow the directions of your physician. Evidence indicates that SAM-e will not work when B12 and folate levels are low. It is suggested to take these supplements while supplementing your diet with SAM-e: 1000 mcg Vitamin B12 and 800 mcg Folic Acid are sufficient. There are several articles available on the internet related to SAM-e and it's benefits.

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Q: What is the best time of day to take SAME?
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