Rouleaux formation occurs when red blood cells form rolls or stacks. If not due to an artifact, such as a result of not preparing the blood smear soon enough after placing the blood on the slide, it may be due to the presence of high concentrations of abnormal globulins or fibrinogen. This formation is found in multiple myeloma and macroglobulinemia.
The red blood cells stack up like coins. http://en.wikipedia.org/wiki/Rouleaux
Autoagglutination should also be distinguished from "Rouleaux formation" wherein normal blood tends to form stacks on keeping, which disperses on dilution with normal saline.
Rouleaux refers to the stacking of red blood cells (erythrocytes) in human blood. Rouleaux formation is enhanced in the presence of increased plasma proteins, leading to an increased erythrocyte sedimentation rate (ESR).
When rouleaux formation is truly present, it is caused by an increase in cathodal proteins, such as immunoglobulins and fibrinogen.And the fibrinogen is not present in blood in vivo*This is not true. Fibrinogen is secreted by liver and is present in blood. The reason rouleaux do not form in vivo is that they only form under low shear stress conditions. With blood flow, the cross-sectional fluid velocity gradient in the blood vessel results in shear stress levels that exceed the threshold for rouleaux formation.
Multiple Myeloma
This question probably is spelled wrong (roulex). A rouleaux formation is: A stacklike arrangement of red blood cells in blood or in diluted suspensions of blood in which their biconcave surfaces are next to each other.
Spring rolls are "des rouleaux de printemps".
rouleaux
The condition is called "Rouleaux".
"Rollers" about surf-waves, for hair, or in painting, "rolling pins" in pastry, and "rolls" of paper, scrolls, and wallpaper are English equivalents of the French word rouleaux. Whatever the meaning or use, the pronunciation remains "roo-lo" in French.
literally "un lit traîneau", but the old bed style "lit à rouleaux" also seems to fit.
To get more information on this particular subject go to the related link "(Is Erythrocyte Sedimentation Rate the Preferable Measure of the Acute Phase Response in Rheumatoid Arthritis?)" below