The amount of methadone it takes to overdose will depend on each individual person. Some factors to consider are how much the person weighs as well as their tolerance to the drug itself.
Yes, dissolving methadone in liquid can increase the risk of overdose because it can be absorbed into the body more rapidly than when taken in pill form. This can lead to respiratory depression, sedation, and other dangerous effects. It is important to use methadone only as prescribed and not to alter the form in which it is taken.