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A golden yellow or yellow-brown insoluble protein produced by phagocytic digestion of hematin; found in most tissues, especially in the liver, spleen, and bone marrow, in the form of granules much larger than ferritin molecules (of which they are believed to be aggregates), but with a higher content, as much as 37%, of iron; stains blue with Perl Prussian blue stain.
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Where is ferritin and hemosiderin stored?
Ferritin and hemosiderin are stored in the liver, spleen, and bone marrow. They are primarily stored in the form of ferritin, a complex of iron and protein, with hemosiderin being a breakdown product of ferritin storage.
How are terms hemoglobin hemosiderin and hemolysis related?
they are related because of blood
What is Perls test?
a test for hemosiderin, utilizing Perls Prussian blue stain.
Why hepatomegaly occurs in thalassemia?
Hepatomegaly in thalassemia occures as aresult of engorgement of hepatic paranchymal and phagocytic cells with hemosiderin deposits.
What is hemosiderin-laden macrophage?
Hemosiderin is an iron-containing pigment derived in humans from ferritin. It can be found in macrophages in small amounts throughout a number of different tissues including the bone marrow, liver and the spleen as a normal way to store iron. Under certain conditions it can pathologically accumulate in excess amounts. In hemosiderosis macrophages are hemosiderin-laden but without associated damage to surrounding tissue. When there more extensive accumulation occurs, it can lead to surrounding tissue damage, scarring and organ dysfunction. This is called hemochromatosis.
What is chief function of hemosiderin?
Haemosiderin is a wear and tear pigment of the cells. It has no function of its on as such it colors the tissue yellow can signify ageing of the cells.
What is the chief function of hemosiderin?
Haemosiderin is a wear and tear pigment of the cells. It has no function of its on as such it colors the tissue yellow can signify ageing of the cells.
Why is iron not stored or transported in its free form?
iron can not be storde or transported in its free form because is toxic. so it stored inside of cells as ferritin and hemosiderin
Which of these proteins functions to store or transport iron?
Ferritin is a protein that functions to store iron in the body. Transferrin is a protein that transports iron in the blood.
What caveat governs use of laser technolpogy in treatment of spider veins?
Argon lasers, however, have been found to increase the patient's risk of developing hemosiderin discoloration when used on the legs.
What are the chances of complication occurrence associated with sclerotherapy?
Hemosiderin discoloration: 10%-80% of patients, with fewer than 1% of cases lasting longer than a year. Telangiectatic matting: 5%-75% of patients. Deep venous thrombosis: Fewer than 1%.
How is iron stores and transported in the body?
Iron taken in excess is stored in two forms ferritin and hemosiderin. Iron that is not used for erythropoiesis is stored in the mononuclear phagocytic system (MPS) or the reticloendothelial (RE) cells of the bone marrow, liver, and spleen. The body transports iron in hemoglobin which is the substance in the red blood cells which binds to oxygen to transport to the whole body.
