A golden yellow or yellow-brown insoluble protein produced by phagocytic digestion of hematin; found in most tissues, especially in the liver, spleen, and bone marrow, in the form of granules much larger than ferritin molecules (of which they are believed to be aggregates), but with a higher content, as much as 37%, of iron; stains blue with Perl Prussian blue stain.
they are related because of blood
a test for hemosiderin, utilizing Perls Prussian blue stain.
ferritin, hemosiderin, and transferrin
Hepatomegaly in thalassemia occures as aresult of engorgement of hepatic paranchymal and phagocytic cells with hemosiderin deposits.
Hemosiderin is an iron-containing pigment derived in humans from ferritin. It can be found in macrophages in small amounts throughout a number of different tissues including the bone marrow, liver and the spleen as a normal way to store iron. Under certain conditions it can pathologically accumulate in excess amounts. In hemosiderosis macrophages are hemosiderin-laden but without associated damage to surrounding tissue. When there more extensive accumulation occurs, it can lead to surrounding tissue damage, scarring and organ dysfunction. This is called hemochromatosis.
Haemosiderin is a wear and tear pigment of the cells. It has no function of its on as such it colors the tissue yellow can signify ageing of the cells.
Haemosiderin is a wear and tear pigment of the cells. It has no function of its on as such it colors the tissue yellow can signify ageing of the cells.
iron can not be storde or transported in its free form because is toxic. so it stored inside of cells as ferritin and hemosiderin
Argon lasers, however, have been found to increase the patient's risk of developing hemosiderin discoloration when used on the legs.
Hemosiderin discoloration: 10%-80% of patients, with fewer than 1% of cases lasting longer than a year. Telangiectatic matting: 5%-75% of patients. Deep venous thrombosis: Fewer than 1%.
Iron taken in excess is stored in two forms ferritin and hemosiderin. Iron that is not used for erythropoiesis is stored in the mononuclear phagocytic system (MPS) or the reticloendothelial (RE) cells of the bone marrow, liver, and spleen. The body transports iron in hemoglobin which is the substance in the red blood cells which binds to oxygen to transport to the whole body.
this is in the left frontal lobe focal encephalomalacia . I would like to now what that means and do i need treatment . there is a axial flair image# 11 there are 2 punctate foci of t2 signal abnormality identified in the subinsusular white matter anteriorly.There is an area of focal encenphalomalacia identified on axial images #. 11 though18 . There is a mild amount of focal increased t2 signal consistent with gliosis in this region . on gradient-echo images there is no signal dropout to indicate hemorrhage or chronic hemosiderin. imag #5&6 there are high t2 signal consistent with cystic change in the post aspectof the clivus. this is also seen on sagittal t1 weighted image #10 there is a mucosal retention cyst in the left posterior ethmoid sinuses otherwise the paranasal sinuses are normal. I have some problems headaches, weakness , clumsiness, difficulty walking,visual changes,difficulty with seech, behavior changes,nausea, i have seen a doctor butt need to have treatment