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In general, creatinine clearance is the removal of creatinine from the body. In renal physiology, creatinine clearance is the volume of blood plasma that is cleared of creatinine per unit time. Clinically, creatinine clearance is a useful measure for estimating the glomerular filtration rate (GFR) of the kidneys.1
Creatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass).2
The result of this test is an important gauge used in assessing excretory function of the kidneys.1
1. http://en.wikipedia.org/wiki/Creatinine_clearance
2. http://en.wikipedia.org/wiki/Creatinine
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