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Hypotonic solutions contain a dissolved solute concentration which is lower than that of inside the cell. Recall that normal saline (NS) is 0.9% sodium chloride, weight/volume (90mg/100mL). A hypotonic solution would have less than 0.9% (or less than 90mg/100mL). A typical hypotonic solution used in hospitals is 1/2 NS, or in certain circumstances, 1/4NS (which pharmacists usually round to 0.3% NaCl).

To think about it biologically, if you were to drop a red blood cell into a hypotonic solution, the cell would engorge with water because its salt concentration is much higher than that of the surrounding environment.

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