Cocaine is an agonist to the dopamine receptor. Because it is an agonist, cocaine sits on the dopamine receptor, thus inducing dopamine chemicals to flood into the brain and body. Dopamine makes a person feel euphoria......
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neurons; dopamine
neurons; dopamine
The could be a stress / trauma related impairment of the dopamine system that results in a reduced capacity to experience pleasure and correlates with addiction. The dopamine recepters are unable or reduced in their ability to reuptake dopamine and thus a flood of dopamine becomes necessary in order to feel any level of pleasue. That's my best guess. Come see me at sonoranhealingcenter.com
that's how the mafia works
PCP is more addictive than LSD because it works on Dopamine Receptors in the reward pathway. Normally, inhibitory neurotransmitters are active in the synapse. These neurotransmitters inhibit dopamine from being released. When endorphins activate the dopamine receptors, the release of inhibitory neurotransmitters is shut down. Without inhibition, dopamine can be released. PCP mimics endorphins and binds to opiate receptors, turning off dopamine inhibition. Dopamine is allowed to flood the synapse, producing immediate feelings of sedation and well-being. 10 bucks says your in Med Chem with Mr. Choi.
When a substance enters a neuron, it can bind to receptor sites on the neuron's membrane, triggering a cascade of events within the neuron. This can lead to changes in the neuron's electrical activity, release of neurotransmitters, or alterations in gene expression, ultimately affecting the neuron's function.
The opposite of dopamine is serotonin.
Cocaine and crack cocaine are psychostimulants that affect neurons containing dopamine in the areas of the brain known as the limbic and frontal cortex. When cocaine is used, it generates a feeling of confidence and power. However, when large amounts are taken, people "crash" and suffer from physical and emotional exhaustion as well as depression.
Dopamine is the neurotransmitter that is lacked in Parkinson's Disease.
a dopamine chaser is one who chases or craves life experiences that trigger excitement, resulting in a dopamine high.