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What is Phenothiazines?

Updated: 9/7/2023
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Phenothiazine: One of a group of tranquilizing drugs with antipsychotic actions thought to act by blocking dopaminergic transmission (messages sent using the substance dopamine) within the brain.

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Q: What is Phenothiazines?
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Are there any drug interactions with phenothiazines?

Because the phenothiazines have anticholinergic effects, they should not be used in combination with other drugs that may have similar effects.


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What are the drug interactions associated with kava kava?

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Ginger can interfere with the digestion of iron- and fat-soluble vitamins. The herb can inhibit warfarin, a blood thinner. Ginger can also interfere with absorption of tetracycline, digoxin, sulfa drugs, and phenothiazines.


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Nobody knows what the exact causes of lichen planus are. We know it can be triggered by taking certain medications, including thiazide diuretics, antimalarials and phenothiazines (a group of tranquilizing drugs with antipsychotic actions). A significant number of skin specialist doctors (dermatologists) believe it might be classified as an autoimmune disease. A higher-than-normal percentage of people with hepatitis C and some other liver diseases have lichen planus.


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The product information for Embeda contains no specific information to warn against combined use with clonopin or fluoxetine. It does however include the following: EMBEDA should be used with great caution and in reduced dosage in patients who are concurrently receiving other central nervous system (CNS) depressants including sedatives, hypnotics, general anesthetics, antiemetics, phenothiazines, other tranquilizers, and alcohol because of the risk of respiratory depression, hypotension, and profound sedation or coma. When such combined therapy is contemplated, the initial dose of one or both agents should be reduced by at least 50%.


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