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Apparent diffusion coefficient (ADC) measures the magnitude of diffusion (of water molecules) within cerebral tissue. A low value for ADC indicates that the cortical white matter tracts are organized (good), while a high value for ADC indicates that these tracts are disorganized (bad). When evaluating an acute ischemic stroke, ADC image sequences play a crucial role. Ischemic brain parenchyma tends to have a low ADC value. This is in turn correlated with a high diffusion weighted imaging (DWI) value to confirm that the ischemia is not secondary to an MRI artifact known as T2 shine through. The latter would demonstrate a high signal on DWI imaging, but would continue to demonstrate high intensity on ADC sequences.

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