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What does a m-protein spike in the gamma region of the protein electrophoresis indicate?
Directly from the AAFP, 1 Jan 05,.several disease states cause a homogenous spike-like peak in a focal region of the gamma-globulin zone of the SPEP.In the interpretation of SPEP, most attention focuses on the gamma region, composed predominantly of the IgG type, however a single spike can occur in the alpha2, and beta regions in patients with multiple myeloma. Monoclonal gammopathies are associated with a clonal process that is malignant or potentially malignant. Multiple myeloma should be ruled out with a bone marrow biopsy, and diagnosis requires 10-15% plasma cell involvement and M-protein level is usually >3g/dL. Hope this sheds some light on the subject. Carl Weathers, RN MCG, Augusta, GA.
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How does EMSA electromobility shift assay measure whether the protein bends DNA?
EMSA does not measure if protein bends to DNA. It does measure what proteins bind to a specific region of DNA (usually a promoter region). You can use a supershift to determine exactly what protein is binding to the specific DNA region.
What are the functions of the N and C terminal regions of a protein?
The N-terminal region of a protein helps in targeting and directing the protein to its correct location within the cell, while the C-terminal region is involved in protein-protein interactions and stability.
What is th blue dye added to the sample before the electrophoresis is performed?
In biochemistry labs, the traditional answer for a protein gel (polacrylamide gel electrophoresis) is bromphenol blue. For a DNA gel (agarose gel electrophoresis), traditionally the same dark blue dye bromphenol blue was combined with the lighter, slower migrating blue dye xylene cyanol. Oftentimes nowwe only use the bromphenol blue, or even substitute for it with Orange G, which is a UV-transparent dye that more easily enables the visualization of smaller molecular weight nucleic acids that migrate in the same region.
The region of a protein that binds a ligand?
The region on a protein that binds a ligand is known as the binding site. This site is typically composed of specific amino acids that interact with the ligand through various chemical bonds and molecular interactions. The binding of the ligand to the protein's binding site is crucial for the protein's function and activity.
What are the differences between the N-terminal and C-terminal regions of a protein?
The N-terminal region of a protein is the starting point of the protein chain, while the C-terminal region is the end point. These regions can have different functions and structures, influencing how the protein functions in the body.
What are the differences between the C-terminal and N-terminal regions of a protein?
The C-terminal region of a protein is located at the end of the protein chain, while the N-terminal region is at the beginning. These regions can have different functions and interactions with other molecules, affecting the overall structure and function of the protein.
Protein strands that attach to the centromere region during M-phase of cell cycle?
During Metaphase the protein strands that attach to the centromere region are called spindle fibres.
What is the difference between the N-terminal and C-terminal regions of a protein?
The N-terminal region of a protein is the end where the amino acid chain starts, while the C-terminal region is where it ends. These regions play a role in the protein's structure and function.
What are the differences between the protein's N-terminal and C-terminal regions?
The N-terminal region of a protein is the end where the amino acid chain starts, while the C-terminal region is where it ends. These regions can have different functions and interactions within the protein structure.
A region of the dna molecule that stores instructions for a protein is called a?
A region of the DNA molecule that stores instructions for a protein is called a gene. Genes are the basic unit of heredity and provide the code for creating proteins through a process called transcription and translation.
What do close flux lines indicate?
There is more magnetic force in that region on a particle.
What is the difference between the C-terminal and N-terminal regions of a protein?
The C-terminal region of a protein is the end where the carboxyl group is located, while the N-terminal region is the end where the amino group is located. These regions play a role in determining the structure and function of the protein.
