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  • ACTH stimulates lipoprotein uptake into cortical cells. This increases the bio-availability of cholesterol in the cells of the adrenal cortex.
  • ACTH increases the transport of cholesterol into the mitochondria and activates its hydrolysis.
  • ACTH Stimulates cholesterol side-chain cleavage enzyme, which makes the rate-limiting step in steroidogenesis. This results in the production of pregnenolone.
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Q: What does ACTH stimulate?
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