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If by "going down on someone" you mean oral sex, then there are diseases to be concerned with, especially if oral sex was provided without a barrier. For unprotected oral sex the following are possibly transmitted: Herpes, Chlamydia, Gonorrhea, Syphillis, HIV, HPV, and even Hepatitis A, mostly with oral to anal.

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Q: What can you catch from going down on someone?
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