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Gelatin capsule can be used to mask the taste of drugs and make the drug easier to swallow. There is no need to compact the material together so the material can be directly filled inside. The material can be filled multiple so that a unique delivery system can be designed within the capsule. As automatic filling machines are used to pump liquids with poorly-soluble drugs dissolved in them into hard shell capsules, it can help improve the content uniformity of these drugs. Hard shell capsules can also be used for modified-release formulations.

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6y ago
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6y ago

Gelatin capsule have a low bulk density so bulky substances may need granulation before the filing process. Capsule filling machines also create tablets slower than tablet presses. Gelatin capsules are also not suitable for very soluble may be suddenly released in the stomach causing irritation. Gelatin capsules are also not that physically stable. They should have an equilibrium moisture content of 13-16%. These capsules are also prone to cross-linking when they are exposed to traces of aldehydes or stored for too long in extreme temperature or humidity. They will ultimately become water-insoluble. HPMC-based capsules can be used to prevent this from happening.

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