The only time a colon cleanse is advised is prior to a colonoscopy.
As Dr. Oz put it, the only reason other than that is if you enjoy the way it feels.
I imagine with the gas, cramping, and bloating that occur while the body rebuilds the essential bacteria in the large intestine, it doesn't feel so pleasant.
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Colon cleanses are said to improve colon health and your overall well being by helping remove built up fecal matter in your digestive tract. They help your body flush out this material and leaving you feeling less bloated.