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That's as vague as asking what does food smell like. There are literally thousands of different drugs, all with different effects. Although there are only about two dozen drugs which are commonly used and 5-6 different classes which most drugs can be categorised under, they still can have somewhat different effects from one another, even if they belong to the same class.

Even the most harmfull ones still need to be taken in fairly large amounts to cause any damage, alcohol generally being one of the most dangerous, addictive and toxic of all drugs, with almost all other drugs being rated as less harmfull as alcohol (see the drug risk comparisson in the Lancet medical journal). One of the rare exceptions which can do permanent damage even with just normal doses and when used just once or twice, are inhalants such as Toluene, Benzene, Acetone and Butane/Propane. They kill massive amounts of braincells and have often proven fatal in relatively moderate doses, with inhalants, there is no "safe" dose.

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