What are causes of optic atrophy?

Answer 1

Definition

Optic nerve atrophy is tissue death of the nerve that carries the information regarding sight from the eye to the brain.

Alternative Names

Second cranial nerve atrophy

Causes, incidence, and risk factors

There are many unrelated causes of optic atrophy. The most common cause is poor blood flow, called ischemic optic neuropathy, which most often affects the elderly. The optic nerve can also be damaged by shock, various toxic substances, radiation, and trauma.

Various eye diseases, most commonly glaucoma, can also cause optic nerve atrophy. In addition, the condition can be caused by diseases of the brain and central nervous system, such as cranial arteritis (sometimes called temporal arteritis), multiple sclerosis, brain tumor, and stroke.

There are also several rare forms of hereditary optic nerve atrophy that affect children and young adults.

Symptoms

Optic nerve atrophy causes dimming of vision and reduction of the field of vision. The ability to see fine detail will also be lost. The pupil reaction to light will diminish and may eventually be completely lost.

Signs and tests

Optic nerve atrophy can be readily detected on complete examination of the eyes. Seeking the cause may require a complete physical examination and specific tests.

Treatment

Once it has occurred, damage from optic nerve atrophy cannot be reversed. The underlying disease must be found and treated, if possible, to prevent further loss.

Expectations (prognosis)

Vision lost to optic nerve atrophy cannot be recovered. If the cause can be identified and controlled, further visual loss progressing to blindness may be prevented.

Complications

Complications will be related to the disease that causes the atrophy.

Calling your health care provider

Patients with optic nerve atrophy will be closely monitored by an ophthalmologist with experience in neuro-ophthalmology. Any change in vision should be reported urgently.

Prevention

Many causes of optic nerve atrophy cannot be prevented. Facial injuries can be prevented by standard safety precautions. Most such injuries are related to motor vehicle accidents and can be prevented by seat belt use.

Methanol is the most common toxin causing optic nerve atrophy. It can be found in home-brewed alcohol. Home-brewed alcohol and forms of alcohol not intended for drinking should never be consumed.

Answer 2

Definition

Optic nerve atrophy is damage to the optic nerve. The optic nerve carries images of what we see from the eye to the brain.

Alternative Names

Optic atrophy; Optic neuropathy

Causes, incidence, and risk factors

There are many unrelated causes of optic atrophy. The most common cause is poor blood flow, called ischemic optic neuropathy, which most often affects elderly people. The optic nerve can also be damaged by shock, various toxic substances, radiation, and trauma.

Various eye diseases, most commonly glaucoma, can also cause a form of optic nerve atrophy. In addition, the condition can be caused by diseases of the brain and central nervous system, such as:

• Brain tumor
• Cranial arteritis (sometimes called temporal arteritis)
• Multiple sclerosis
• Stroke

There are also several rare forms of hereditary optic nerve atrophy that affect children and young adults.

Symptoms

Optic nerve atrophy causes vision to dim and reduces the field of vision. The ability to see fine detail will also be lost. Colors will seem faded. The pupil reaction to light will diminish and may eventually be lost.

Signs and tests

Optic nerve atrophy can be seen during a complete examination of the eyes. The examination will include tests of:

• Color loss
• Pupil light reflex
• Tonometry
• Visual acuity

You may need a complete physical examination and specific tests.

Treatment

Damage from optic nerve atrophy cannot be reversed. The underlying disease must be found and treated, if possible, to prevent further loss.

Rarely, conditions that lead to optic atrophy may be treatable.

Expectations (prognosis)

Vision lost to optic nerve atrophy cannot be recovered. If the cause can be found and controlled, further vision loss and blindness may be prevented. It is very important to protect the other eye.

Complications

Complications are related to the disease that causes the atrophy.

Calling your health care provider

Patients with optic nerve atrophy will be closely monitored by an ophthalmologist who has experience in neuro-ophthalmology. Tell your doctor right away about any change in vision.

Prevention

Many causes of optic nerve atrophy cannot be prevented.

Ways to protect yourself include:

• Older adults should have their health care provider carefully manage their blood pressure.
• Prevent injuries to the face by using standard safety precautions. Most injuries to the face are related to motor vehicle accidents and can be prevented by using seat belts.
• Schedule a routine annual eye exam to check for glaucoma.

Methanol, which is found in home-brewed alcohol, can cause optic nerve atrophy in both eyes. Never drink home-brewed alcohol and forms of alcohol that are not intended for drinking.

References

Balcer LJ, Brasad S. Abnormalities of the optic nerve and retina. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J, eds. Neurology in Clinical Practice. 5th ed. Philadelphia, Pa: Butterworth-Heinemann;2008:chap 15.

Arnold AC. Ischemic optic neuropathies. In: Yanoff M, Duker JS, eds. Ophthalmology. 3rd ed. St. Louis, Mo: Mosby Elsevier;2008:chap 9.7.

Wax M, Clark A, Civan MM. Mechanisms of glaucoma. In: Yanoff M, Duker JS, eds. Ophthalmology. 3rd ed. St. Louis, Mo: Mosby Elsevier;2008:chap 10.3.

Reviewed By

Review Date: 07/28/2010

Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; and Franklin W. Lusby, MD, Ophthalmologist, Lusby Vision Institute, La Jolla, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Answer 3

Causes of optic atrophy include: optic neuritis, Leber's hereditary optic atrophy, toxic or nutritional optic neuropathy, glaucoma, vascular disorders, trauma, and other systemic disorders

Answer 4

They get it from poor blood flow.