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The question is flawed. Substance can mean element or molecule. I'll go with molecule since organic simply means carbon atoms are present. Hydrogen dioxide is the most abundant inorganic "substance".

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Q: The most abundant inorganic substance in the human body is?
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The most abundant chemical substance in the human body?

Water is the most abundant chemical substance in the human body, making up approximately 60% of a person's body weight.


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The second most abundant substance in the human body is proteins. Proteins are essential for various functions in the body, including building and repairing tissues, supporting the immune system, and serving as enzymes and hormones.


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An inorganic substance needed by the human body for good health.


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