The Malate Aspartate shuttle is responsible for?

Answer 1

In gluconeogenesis, the first set of enzimes need to turn pyruvate or oxaloacetate into PEP. The enzimes needed to convert PEP into glucose (after many steps) are located in the cytoplasm. As you might recall, glycolisis occrurs in the cytoplasm while TCA (and hence Oxaloacetate) occurs in the mitochondrion.

THE MALATE ASPARTATE SHUTTLE WILL TRANSPORT OXALOACETATE FROM THE MITOCHONDRION INTO THE CYTOPLASM so it can follow all the other reactons that will lead to glucose.