Decrease heart rate & increase cardiac output
Beta antagonist medications are given to people that have abnormally low heart rates. The mechanism of these medications on the heart is to allow the heart to beat faster.
When beta receptors are stimulated, it decreases the heart rate to treat for low blood pressure.
Beta 1 receptors
There are at lest 3 types of beta receptors and they are found in different organs. Beta-1 (β1) receptors are found in the heart, eye, and kidneys while beta (β2) receptors are found in the lungs, gastrointestinal tract, liver, uterus, blood vessels, and skeletal muscle. The third type, beta (β3) receptors are found in fat cells.
To understand how beta adrenergic blockade lowers blood pressure, you need to understand a little physiology. Beta receptors are present in many different places in the body: the heart, the blood vessels, the kidneys, the lungs, the muscles, etc. They perform different tasks in each different place as well, and there are different classes of receptors. For instance, in the heart, the receptors are called beta-1 receptors and they increase the rate of firing of the SA node (chronotropy), increases cardiac conduction velocity (dromotropy) and increase the strength with which the heart beats (inotropy). In the arterioles, the receptors cause dilatation of the vessels and are called beta-2 receptors. In the kidneys, beta-1 receptors increase renin output from the juxtamedullary cells when stimulated. Renin is an enzyme that produces a potent vasocontrictor when it activates the angiotensin cascade. Now, how does beta antagonism lower blood pressure. First, in the heart, beta blockade causes a slowing of the heart rate and stroke volume, effectively decreasing cardiac output. In the kidneys, beta blockade decreases renin release, which decreases the amount of systemic vasoconstrictors in the body. These two effects cause the blood pressure to decrease over time.
beta 1 receptors
Beta 2 receptors are responsible for keeping your bronchi open so you can breath. If they are antagonized, your bronchi will close up. In asthma you want to use Beta2 AGONISTS, drugs that stimulate these receptors, so you can breath.
In medicine, an antagonist is a substance that interferes with or inhibits the physiological action of another substance. Antagonists are often used to block receptors or inhibit the effects of certain neurotransmitters or drugs in the body. Examples include beta-blockers, which are antagonists of beta-adrenergic receptors.
beta receptors
Beta adrenergic agents serve as inhibitors that prevent beta adrenergic substances (neurotransmitters) such as epinephrine from binding to beta adrenergic receptors (beta 1, beta 2 and beta 3). This prevents the effects of the neurotransmitters thereby reducing blood pressure and heart rate.
side effects include drowsiness, decreased libido, fatigue, and especially worsening of asthma, breathing difficulty if you have pre-existing lung conditions such as COPD/bronchitis/pneumonia/Cystic Fibrosis. Beta blockers should be used only sparingly in heart failure, because of the vulnerability to enter into pulmonary edema.
Propranolol acts on the beta-adrenergic receptors anywhere in the body, and has been used as a treatment for emotional anxiety and rapid heart beat.
alpha 1, alpha 2, beta 1, beta 2