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Pantoprazole (Protonix) apparently does not interfere with the liver enzyme system involved in the absorption of Plavix. This difference means it should not interfere with the efficacy of Plavix. I am currently trying to decide whether to discontinue taking a different PPI (proton pump inhibitor) and switch to pantoprazole (Protonix). I have been taking a PPI for many years because of severe GERD, and, for the past two years, I have been on Plavix following an embolic event related to carotid artery disease. At this point, I am switching to pantoprazole, and, will stagger when I take the Plavix and the PPI (based on the absorption of Plavix). I have been taking a PPI for many years, and, for the past two years, I have been on Plavix following an embolic event related to carotid artery disease. At this point, I am switching to pantoprazole, and, will stagger when I take the Plavix and the PPI (based on the absorption of Plavix).

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15y ago

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