Heparin is not a low molecular weight heparin
I'm thinking that the 5000 you are referring to is 5000 units because 5000 units administered subcutaneously two or three times daily as a pretty standard dose for preventing blood clots with heparin
heparin/low molecular weight heparin
the half life of heparin is 2 hours and that of low molecular weight heparin (LMWH) is 4 hours
Standard heparin, an effective treatment for antepartum thromboembolic disease, is thought to be safe for the fetus since it does not cross the placenta. Recently, a number of low molecular weight heparins have been prepared which have been shown to produce less bleeding than standard heparin for an equivalent antithrombotic effect in experimental animals. These observations suggest that the low molecular weight heparins may also provide superior antithrombotic therapy in antepartum thromboembolic disease. However, it is not known whether the low molecular weight heparins cross the placenta. To determine this, we examined the pharmacokinetics of 125I-labelled standard heparin and a low molecular weight heparin, and their anticoagulant effects in mother and fetus, using a pregnant sheep model. Catheters were inserted into maternal and fetal femoral arteries at 108-119 d gestation (term: 147 d). 1-3 days later the mothers were given a bolus i.v. injection of 5000 anti-Xa units of 125I-labelled standard heparin or low molecular weight heparin, CY 222. Nine serial blood samples were collected over 4 h from both mother and fetus for measurements of radioactivity, anti-Xa activity (chromogenic) and activated partial thromboplastin times. When therapeutic levels of standard and CY 222 heparins were achieved in the mother, there was no detectable radioactivity or anticoagulant effect in the fetus. We conclude that standard heparin and the low molecular weight CY 222 do not cross the placenta in the pregnant sheep.
Trevor David Power has written: 'Derivatization of low molecular weight heparin with polyethylene glycol monomethyl ether (MPEG)' -- subject(s): Heparin, Chemistry, Methyl ether
This is a catalyst.
Fragmin/Heparin a low-molecular-weight heparin is a new DVT treatment. It's effective within hours, reducing complications and hospitalizations. You can do the injections at home, once or twice daily, on an outpatient basis. And because it is more consistent and predictable, it doesn't require regular blood tests. Also the duration of action of a single dose of warfarin is 2 to 5 days.
The absolute value of molecular weight (molar mass) is somewhat arbitrary. It's like asking if 100 is a large number, small number or somewhere in between. There are molecular weights as low as, say 2 g/mole for H2 gas, and as high as several thousand for a protein or other polymer. So, a molecular weight of 84 is high compared to a MW of 2, but is low compared to a MW of 100,000.
Biomolecules contain protoplasm which other molecules do not contain. Micromolecules are with low molecular weight e.g glucose, water. Macromolecules are with high molecular weight e.g starch, protein etc.
yes, Dextrins are a group of low-molecular-weight carbohydrates produced by the hydrolysis of starch or glycogen.
the molecular form is E+061-0h2= the molecular form of sweet the molecular form for low is LL-082+ 56E-541= form for low