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Donepezil hydrochloride (donepezil HCI) is and inhibitor used to treat and improve cognition in patients with vascular dementia and Alzhemimer's. Donepezil HCI is most commonly used with Alzheimer's patients. But it is also, used with patients with vascular dementia. This medication is most beneficial for those with mild to moderate vascular dementia, but it is also helpful for those with severe dementia. Donepezil HCI has a positive impact on the flow of blood in the brain, thereby assisting with concentration and memory deficits. This drug can cause possible side effects appetite loss, diarrhea, muscle cramps, fatigue, sleeping disturbance, hallucinations and vomiting.

Vascular Dementia (VaD) is due to a loss in the brain function; behavioral, comprehension, intellectual impairment, judgment, language, memory, mental functions, motor symptoms, reasoning, thinking, and they can also develop exaggerated neurological symptoms, such as exaggerated balance issues causing swaying and falling, arm or leg reflexes, and exaggerated steps when attempting to walk.

Vascular dementia impairment is the second most common disorder and similar to Alzheimer's disease. But its impairment can come on more suddenly than Alzheimer's, however it can also come on slowly; this disorder comes on quickly, it is progressive, with worsening cognitive functions and memory. The cause is due to the reduced flow of blood inside the brain, generally due to a mini-stroke, stroke, or a series of strokes. The extent of VaD varies depending on the part of the brain affect due to lack of blood flow. There are times when a person with VaD can experience extended period with no noticeable changes in their symptoms.

SOME OTHER USES: On and off label -- brain trauma; auditory and visual issues; Lewy body dementia; autism; down syndrome; stroke patients (without dementia); menstruation issues; diuretic; intestinal angioedema; mild traumatic brain injury; hyperactivity disorder; and behavioral disorders.

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Q: Is donepezil used only for dementia?
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Acetylcholinesterase inhibitors help to prevent the breakdown of acetylcholine, a neurotransmitter which functions suboptimally in dementia of the Alzheimer's type (Aricept and others). Also, NMDA receptor antagonists help to promote excitatory neurotransmitter function (Namenda).

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