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The results of some studies suggest that creatine supplementation does enhance performance of short-term, repetitive, high-intensity activity such as weight lifting or sprinting, but it has not been shown to benefit endurance activity. The use of creatine supplements has not been studied enough to confirm whether or not it is completely safe, but currently the supplements are considered safe for healthy adults. In a study of 23 football players, long-term use (21 months) of creatine supplements revealed no adverse effects on kidney or liver function. More research is needed, however, to confirm the safety of long-term creatine use. Creatine supplementation may pose risks to athletes with kidney disease or other conditions. One side effect of creatine supplementation that no one disputes is weight gain. For some athletes, weight gain, especially muscle gain, is beneficial, but for others, it is not.

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