warfarin ⇔ amoxicillin
Moderate Drug Interaction
Applies to: Coumadin (warfarin) and amoxicillin
MONITOR: Penicillins may occasionally potentiate the risk of bleeding in patients treated with oral anticoagulants. The exact mechanism of interaction is unknown but may involve penicillin inhibition of platelet aggregation. In one study, defective platelet aggregation occurred with predictability in patients receiving penicillin G 24 million units/day, ampicillin 300 mg/kg/day, and methicillin 300 mg/kg/day. Other penicillins such as nafcillin, piperacillin, and ticarcillin have also been found to affect platelet function, and benzylpenicillin and carbenicillin have been reported to increase bleeding times and cause bleeding in the absence of an anticoagulant. There have been case reports describing increases in prothrombin time and INR as well as spontaneous bruising and bleeding in anticoagulated patients following initiation or completion of penicillin therapy. Although most cases have involved large, intravenous doses of some penicillins (e.g., carbenicillin, penicillin G, ticarcillin), the interaction has also been reported with regular, oral doses of amoxicillin and amoxicillin-clavulanate. In fact, a case-control study found amoxicillin-clavulanate to be one of only two medications to significantly increase the risk of overanticoagulation in previously stable outpatients treated with phenprocoumon or acenocoumarol. In that study, 300 outpatients at a Netherlands anticoagulant clinic who presented with an INR value greater than or equal to 6.0 (median value 6.8) were compared with 302 randomly selected matched controls with INR values within the target range (median value 3.2), and changes in the use of 87 potentially interacting drugs or drug classes in the four weeks prior to the index day were identified and analyzed. A course of amoxicillin-clavulanate increased the risk of overanticoagulation even after adjustment for potential confounding factors, particularly in patients treated with acenocoumarol. A follow-up study focusing on antibiotic use in outpatients treated with phenprocoumon or acenocoumarol at a different Netherlands anticoagulant clinic also identified amoxicillin use as a risk factor for overanticoagulation, with the relative risk most strongly increased four days or more after start of the antibiotic. MANAGEMENT: Caution is recommended if a penicillin is prescribed during oral anticoagulant therapy, especially in the elderly and patients with uremia or hepatic impairment. The INR should be checked frequently and anticoagulant dosage adjusted accordingly, particularly following initiation or discontinuation of penicillin therapy in patients who are stabilized on their anticoagulant regimen. Patients should be advised to promptly report any signs of bleeding to their doctor, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
There are no known dangerous interactions between the two medicines.
( www dot coumadin dot com/pdf/Interactions_With_COUMADIN.pdf ) For a full list of interactions see the document above on the Coumadin website According to this document on the Coumadin website Xanax has the potential to increase the effects of Coumadin and your INR under the heading of: Examples of CYP450* Interactions with COUMADIN -Anthony
what is the difference is it for a ear infection
Vitamin K has serious interactions with some blood thinner (such as warfarine - Coumadin). This interaction is very important and should be monitored very closely.
No. The only drugs that I have been informed that will affect that form of birth control are Tuberculosis meds and Seizure meds.
I am prescribed cymbalta for depression. Can I take Amberen while I'm on cymbalta
No, you may take vinegar with amoxicillin if you want to.
There are no known drug interactions between amoxicillin and Paragard or Mirena. Although Mirena has hormonal action, the hormone is not absorbed via the intestine, rendering moot the concern that broad-spectrum antibiotics can alter the intestinal flora and thereby alter the absorption of estrogen from birth control pills.
Changes in Coumadin (warfarin) levels can be influenced by factors like diet, medication interactions, liver function, alcohol consumption, genetics, and certain medical conditions. Regular monitoring of the international normalized ratio (INR) is necessary to ensure the appropriate dosage of Coumadin is maintained.
Before combining any prescription medications is it wise to consult with the doctor and or pharmacist to avoid unwanted interactions. There is the possibility that blood pressure would be impacted with the combination of Cialis and Amoxicillin.
First drug is plane amoxicillin and second one is amoxicillin with clavulanic acid. Clavulanic acid adds to the efficacy of amoxicillin in most infections.
Pradaxa is not supposed to have any interactions with food, drink or other medications , that is the advantage of it over Coumadin, at least that is what their claim is