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It would normally mean that the persons penis was infected - or to be more clinical, an STD.

In Hersames against Dumas we see the term 'infectious' reffering to the genetalia of the four cowards being cooked in a saucepan to get rid of the 'infections' that the prostitutes have bestowed upon them.

It's basic fisics.

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Q: In will Shakesperes time what does infectious mean?
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